Oxford University coronavirus vaccine promising signs in monkey trials
Coronavirus vaccine hope as Oxford University’s experimental jab prevents the infection from penetrating the lungs in monkeys
- Six rhesus macaques showed signs of antibodies within 28 days of vaccination
- Antibodies are released by immune system and give protection against the virus
- Researchers found the monkeys were able to fight off virus without lung damage
- Here’s how to help people impacted by Covid-19
Hopes a coronavirus cure could be on the horizon were raised today after a vaccine developed in Britain showed promising signs in trials on monkeys.
The University of Oxford’s experimental jab strengthened the immune system in six rhesus macaques without causing any side effects.
Within 28 days of being vaccinated, all of the animals had COVID-19 antibodies – produced by the body to give it some immunity from the virus.
Researchers said the primates were able to fight off the virus before it penetrated deep into their lungs, where it can become deadly.
The promising results come as human trials of the Oxford University vaccine are already underway.
A coronavirus vaccine developed in Britain has showed promising signs in trials on monkeys. Pictured: A volunteer is injected with a vaccine in Oxford University’s vaccine trial
Scientists commenting on the study have described the findings as ‘very encouraging’, but warn it does not guarantee the same results in humans.
They found a single vaccination dose was also effective in preventing damage to the lungs in the study on monkeys and mice.
Some of the animals showed antibodies to the virus within two weeks, but all of them had the virus-fighting molecules within 28 days.
The researchers found viral loads in the lower respiratory system were significantly reduced in the animals given the vaccine.
It suggests the jab prevents the disease from multiplying and spreading deep in the lungs.
The science behind both vaccine attempts hinges on recreating the ‘spike’ proteins that are found all over the outside of the COVID-19 viruses.
Both will attempt to recreate or mimic these spikes inside the body. The difference between the two is how they achieve this effect.
Imperial College London will try to deliver genetic material (RNA) from the coronavirus which programs cells inside the patient’s body to recreate the spike proteins. It will transport the RNA inside liquid droplets injected into the bloodstream.
The team at the University of Oxford, on the other hand, will genetically engineer a virus to look like the coronavirus – to have the same spike proteins on the outside – but be unable to cause any infection inside a person.
This virus, weakened by genetic engineering, is a type of virus called an adenovirus, the same as those which cause common colds, that has been taken from chimpanzees.
If the vaccines can successfully mimic the spikes inside a person’s bloodstream, and stimulate the immune system to create special antibodies to attack it, this could train the body to destroy the real coronavirus if they get infected with it in future.
The same process is thought to happen in people who catch COVID-19 for real, but this is far more dangerous – a vaccine will have the same end-point but without causing illness in the process.
Stephen Evans, an epidemiologist at the London School of Hygiene and Tropical Medicine, said the results were ‘very definitely’ good news.
He said: ‘The most important finding to me is the combination of considerable efficacy in terms of viral load and subsequent pneumonia, but no evidence of immune-enhanced disease.
‘The latter has been a concern for vaccines in general, for example with vaccines against respiratory syncytial virus (RSV), and for SARS vaccines.
‘This was a definite theoretical concern for a vaccine against SARS Cov-2 and finding no evidence for it in this study is very encouraging.’
Dr Penny Ward, professor of pharmaceutical medicine at King’s College London, said: ‘It is helpful to see that monkeys vaccinated with this SARS-CoV-2 vaccine did not have any evidence of enhanced lung pathology and that, despite some evidence of upper respiratory tract infection by SARS COV2 after high viral load virus challenge, monkeys given the vaccine did not have any evidence of pneumonia.
‘These results support the ongoing clinical trial of the vaccine in humans, the results of which are eagerly awaited.’
The paper has not yet been published in a scientific journal or scrutinised by other scientists.
Developing vaccinations usually takes many months or years but researchers around the world are racing towards human trial – including two teams in the UK.
They say the process has been made easier because the virus is not mutating and is similar to other viruses seen in the past.
Researchers from Oxford University, started human trials last month, while a separate team from Imperial College London are due to start testing the jabs on humans in June.
While the Oxford vaccine will try to stimulate the immune system using a common cold virus taken from chimps, the researchers at Imperial are using droplets of liquid to carry the genetic material they need to get into the bloodstream.
Both will then work, in theory, by recreating parts of the coronavirus inside the patient and forcing their immune system to learn how to fight it.
The Oxford vaccine, known as ChAdOx1 nCoV-19 will be trialled on up to 510 people out of a group of 1,112, all of whom will be aged 18 to 55.
The Imperial College Hospital in London is involved in the trial of the Oxford vaccine – it is not yet trialling the vaccine made by the university with which it shares its name.
Oxford’s effort will take six months and is limited to a small number of people so scientists can assess whether it is safe and effective without using huge amounts of resources – each patient must return for between four and 11 visits after the jab – and without the risk of large numbers of people being affected if something goes wrong.
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